Despair is contagious...and death, it appears, is as well!
Monokuma has infected his captives with the Despair Disease, which manifests itself as cowardice in the powerful Owari, gullibility in the worldly Mioda, and dishonesty in the, er...in Komaeda. Fearing that they might commit murder while out of their minds, the sick students are quarantined, with the “healthy” students kept in touch via video monitor...only to discover that the killing hasn't stopped despite their precautions!
Danganronpa 2: Goodbye Despair is a retelling of the events of Danganronpa 2: Ultimate Luck, Hope, and Despair from the manga Danganronpa 2. That series told the story through the eyes of Nagito Komaeda, the "Ultimate Lucky Student," and now Goodbye Despair tells the story through the eyes of Hajime Hinata, his arch-rival in the desperate classroom murder game.